Clinical trials

The following clinical trials are being supported: University Medical Center Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie

• Since December 2009: Retrospective study to correlate scores of neuropsychologic test with regional gray matter volumes of the brain for MCI and mild dementia patients.

  First results:

  • S. Arlt, L. Spies, R. Buchert, M. Eichenlaub, J. Lehmbeck und H. Jahn, "Korrelationen zwischen neuropsychologischen Domänen und regionalem Volumen der grauen Hirnsubstanz bei Patienten mit leichten kognitiven Störungen und Demenzerkrankungen" presented at DGPPN 2010 in Berlin
  • S. Arlt, L. Spies, R. Buchert, M. Eichenlaub, J. Lehmbeck und H. Jahn, "Association between fully automated MRI based volumetry of different brain regions and neuropsychological test performance in patients with mild cognitive impairment and early dementia", submitted to Journal of Psychiatric Research, April 2011

Stadtspital Waid, Memoryklinik, Zürich

• Since November 2010: Prospective, longitudinal study to investigate hippocampal atrophy combining voxelbased morphometry and volumetry as a prognostic marker in MCI and SCI patients.
• Since August 2010: Retrospective study to correlate hippocampal atrophy combining voxelbased morphometry and volumetry with the clinical diagnosis of Alzheimer dementia for a heterogenous population of patients visiting the memory clinic.

  First results:

  • U. Anker, "Validierung der voxelbasierten Volumetrie / Morphometrie der Firma BBS gegenüber der klinischen Diagnose einer Alzheimererkrankung im Patientenkollektiv der Memoryklinik des Stadtspital Waid Zürich" Master Thesis, Berner Fachhochschule, 2011.

Katonsspital Winterthur and Eidgenössische Technische Hochschule (ETH), Zürich

• Since February 2011: Pilot study to evaluate novel imaging biomarker, such as perfusion MRI, MRI spectroscopy, diffuiosn MRI and voxelbased morphometry and volumetry for supporting differential diagnosis of Morbus Alzheimer, Lewy Body Dementia, frontotemporal dementia and corticobasal degeneration.

Goethe-Universität Frankfurt am Main, Klinik für Psychiatrie, Psychosomatik und Psychotherapie

• Since March 2011: Prospective study to evaluate imaging biomarkers combining voxelbased morphometry and volumetry to support early diagnosis of Morbus Alzheimer for MCI and SCI patients in clinical routine.

Dr. Horst Schmidt Klinik (HSK), Klinik für Psychiatrie und Psychotherapie, Wiesbaden

• In preparation: Prospective study to identify imaging biomarkers combining voxelbased morphometry and volumetry for depressed and schizophrenic patients.